Synthesis and some transformations of γ-(p-fluorophenyl)-γ-(2-furyl)propylamine |
| |
| Authors: | N S Arutyunyan L A Akopyan G M Snkhchyan O A Papoyan G A Panosyan G A Gevorgyan |
| |
| Institution: | (1) A. L. Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of the Republic of Armenia, Erevan, 375014;(2) Molecule Structure Research Center, National Academy of Sciences of the Republic of Armenia, Erevan, 375014 |
| |
| Abstract: | Ethyl α-cyano-β-(p-fluorophenyl)-β-(2-furyl)propionate was obtained by the condensation of ethyl α-cyano-β-(2-furyl)acrylate
with p-fluorophenylmagnesium bromide. Its deethoxycarbonylation led to β-(p-fluorophenyl)-β-(2-furyl)propionitrile. Reduction
of the nitrile with lithium aluminum hydride gave γ-(p-fluorophenyl)-γ-(2-furyl)propylamine. Some transformations of the latter
were studied.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 503–509, April, 2006. |
| |
| Keywords: | γ -(p-fluorophenyl)-γ -(2-furyl)propylamine ethyl furfurylidenecyanoacetate ethyl β -(p-fluorophenyl)-β -(2-furyl)propionate reduction deethoxycarbonylation |
| 本文献已被 SpringerLink 等数据库收录！ |
