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A simple and efficient large-scale synthesis of 3-hydroxyphthalans via oxa-Pictet-Spengler reaction catalyzed by nanosilica sulfuric acid |
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| Authors: | Zahra KhorsandiAhmad Reza Khosropour Valiollah MirkhaniIraj Mohammadpoor-Baltork Majid MoghadamShahram Tangestaninejad |
| Institution: | Catalysis Division, Department of Chemistry, Faculty of Science, University of Isfahan, Isfahan 81746-7344, Iran |
| Abstract: | Nanosilica sulfuric acid is found to be a new, powerful and reusable heterogeneous catalyst for the rapid synthesis of 3-hydroxyphthalans via condensation of aromatic aldehydes and 3-hydroxybenzyl alcohols under conventional heating and microwave irradiation. Scale-up preparation of these heterocycles is also carried out. |
| Keywords: | Phthalans 3-Hydroxybenzyl alcohol Aryl aldehyde Oxa-Pictet-Spengler reaction Nanosilica sulfuric acid Microwave irradiation |
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