Regioselective Heteroannelation in 4-Cyanomethyl-3,5-pyridinedicarbonitriles. Synthesis of 6-Alkoxy-3-dialkylamino-1,8-diamino-2,7-naphthyridine-4-carbonitriles |
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| Authors: | Anton V Tverdokhlebov Elizaveta V Resnyanska Andrey A Tolmachev Alexander V Zavada |
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| Institution: | (1) Kiev National Taras Shevchenko University, 01033 Kiev, Ukraine, UA;(2) Chernigov State University of Technology, 14027 Chernigov, Ukraine, UA |
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| Abstract: | Summary. The title naphthyridines were found to be the sole products obtained after treatment of 2-amino-4-cyanomethyl-6-dialkylamino-3,5-pyridinedicarbonitriles
with alkoxides. The starting pyridine derivatives were prepared by amination of the readily available 2-amino-6-chloro-4-cyanomethyl-3,5-pyridinedicarbonitrile
in quantitative yields.
Corresponding author. E-mail: atver@mail.univ.kiev.ua
Received November 4, 2002; accepted November 22, 2002
Published online May 6, 2003 |
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| Keywords: | , Alkoxides, Heterocycles, 2,7-Naphthyridines, Nucleophilic substitutions, Pyridinedicarbonitriles, |
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