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Design,synthesis and biological activity of some novel benzimidazole derivatives against Coxsackie virus B_3 |
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| Authors: | Zhong Lv Zhanga Zhi Jie Suna Fei Xuea Xian Jin Luo Nai Yun Xiub Li Tengc Zong Gen Peng a School of Chemistry Chemical Engineering Shanghai Jiaotong University Shanghai PR China b School of Life Science Environmental Science Shanghai Normal University Shanghai PR China c Institute of Medicinal Biotechnology Chinese Academy of Medical Science Peking Union Medical College Beijing PR China |
| Affiliation: | a School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, Shanghai 200240, PR China;b School of Life Science and Environmental Science, Shanghai Normal University, Shanghai 200234, PR China;c Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, PR China |
| Abstract: | A series of novel benzimidazole derivatives was synthesized and their anti-Coxsackie virus B3(CVB3) activity was evaluated in VERO cells. Compounds 9 and 10 exhibited better inhibitory activity than those of ribavirin (RBV) with IC50 values of 5.30 and 1.06 μg/mL, respectively. |
| Keywords: | Benzimidazole Coxsackie virus B3 (CVB3) Furan Anti-CVB3 activity |
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