| 液相色谱法测定环氧氯丙烷工业中间体中的己二酸 |
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| 引用本文： | 谯应召,华威,张思宝,李洪宽,马金凤.液相色谱法测定环氧氯丙烷工业中间体中的己二酸[J].化学分析计量,2013(6):53-55. |
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| 作者姓名： | 谯应召 华威 张思宝 李洪宽 马金凤 |
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| 作者单位： | [1]山东省化工研究院,济南250014 [2]山东爱纳分析仪器技术服务中心,济南250014 |
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| 摘 要： | 建立了液相色谱仪测定环氧氯丙烷工业中间体中己二酸含量的方法。样品采用甲醇-10mm01／L磷酸缓冲液（体积比5：95）溶液提取，C18固相萃取柱净化，紫外检测器检测，外标法定量。己二酸在100～2000mg／L范围内线性良好，相关系数大于0．9999，按10s／Ⅳ计算，己二酸定量限为25．0mg／kg。添加回收率为91．1％～112．2％．测定结果的相对标准偏差为4．7％～7．9％（n=5）。该方法简单快速，回收率高，重现性好，满足工业分析要求。
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| 关 键 词： | 己二酸 环氧氯丙烷工业中间体 液相色谱法 |
Determination of Adipic Acid in Epoxy Chloropropane Industrial Intermediates by Liquid Chromatography |
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| Qiao Yingzhao,Hua Wei,Zhang Sibao,Li Hongkuan Shandong Chemical Industry Research Institute,Jinan,China Ma Jinfeng.Determination of Adipic Acid in Epoxy Chloropropane Industrial Intermediates by Liquid Chromatography[J].Chemical Analysis And Meterage,2013(6):53-55. |
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| Authors: | Qiao Yingzhao Hua Wei Zhang Sibao Li Hongkuan Shandong Chemical Industry Research Institute Jinan China Ma Jinfeng |
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| Institution: | Qiao Yingzhao, Hua Wei, Zhang Sibao, Li Hongkuan ( Shandong Chemical Industry Research Institute, Jinan 250014, China ) Ma Jinfeng ( Shandong Ai＇ na Analysis Instrument Technology Service Center, jinan 250014, China ) |
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| Abstract: | A method for determination of adipic acid in epoxy chloropropane industrial intermediates by liquid chromatography was established. The sample was extracted by methanol-10 mmol/L phosphate buffer and cleaned up with C18 solid-phase, then analyzed by UV detector and quantified by the external standard method. Good linear relation was obtained in the range of 100-2 000 mg/L with the correlation coefficient more than 0.999 9, the limit of quantitation was 25.0 mg/kg（10S/N）. The recoveries was 91.1%-112.2% with RSD of 4.7%-7.9%（n=5）. The method is simple and fast with high recovery rate, good reproducibility, and meets the demand of industrial analysis. |
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| Keywords: | adipic acid epoxy chloropropane industrial intermediates liquid chromatography |
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