Three new triterpenoid saponins from the roots of Ardisia crenata and their cytotoxic activities |
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Authors: | Dai-Lin Liu Xue Zhang Yanmin Zhao Nai-Li Wang Xin-Sheng Yao |
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Affiliation: | 1. Tianjin Key Laboratory for Prevention and Control of Occupational and Environmental hazard, Tianjin, P.R. China;2. Department of Pharmacognosy, Logistics University of Chinese People’s Armed Police Forces, Tianjin, P.R. Chinadailinlch@163.com;4. Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang, P.R. China |
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Abstract: | Three new triterpenoid saponins, ardisicrenoside O (1), ardisicrenoside P (2) and ardisicrenoside Q (3) together with three known compounds, 3β,16α-dihydroxy-30-methoxy-28, 30-epoxy-olean-12-en, cyclamiretin A 3-O-β-d-glucopyranosyl-(1→2) -α-l-arabinopyranoside and cyclamiretin A 3-O-β-d-glucopyranosyl-(1→4) -α-l-arabinopyranoside were isolated from the roots of Ardisia crenata Sims. Their structures were determined by one- and two-dimensional NMR techniques, including HSQC, HMBC and TOCSY experiments, as well as acid hydrolysis and GC analysis. All isolates were evaluated for the cytotoxic activities on two human cancer cell lines and compounds 3, 5 and 6 showed significant cytotoxicity. |
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Keywords: | Ardisia crenata Sims oleanane triterpenoid saponins cytotoxicity |
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