A practical and green approach towards synthesis of multisubstituted imidazoles using boric acid as efficient catalyst |
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Authors: | Feifei Zhang Qi Gao Bang Chen Wei Sun Dongxu Lv |
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Institution: | Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, P.R. China |
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Abstract: | An efficient one-pot, cyclocondensation of ammonium acetate, 1,2-diphenyl ethanedione, aromatic aldehyde or arylamine, and catalyzed by boric acid is achieved to form multisubstituted imidazole derivatives. Boric acid as green property is harmless to the environment and has improved the yield of multisubstituted imidazole derivatives. Moreover, we have tested the biological activities of imidazole derivatives by the four fungi. And the investigations showed most of imidazole derivatives have antifungal action on four fungus. |
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Keywords: | Imidazole boric acid bioactivity one-pot |
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