Chemical composition of the essential oil from the leaves of Anaxagorea brevipes (Annonaceae) and evaluation of its bioactivity |
| |
| Authors: | Danielle Cardoso de Alencar Maria Lúcia Belém Pinheiro José Lamak da Silva Pereira João Ernesto de Carvalho Francinete Ramos Campos Alessandra Freitas Serain |
| |
| Affiliation: | 1. Departamento de Química, Universidade Federal do Amazonas, Manaus, Brazil;2. Divis?o Farmacologia e Toxicologia, CPQBA, UNICAMP, Campinas, Brazil;3. Departamento de Farmácia, Universidade Federal do Paraná, Campus Jardim Botanico, Jardim Botanico, Curitiba, Brazil;4. Departamento de Biologia Vegetal, PPG BTPB and PPG BV, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil |
| |
| Abstract: | The essential oil obtained by hydrodistillation from leaves of Anaxagorea brevipes was analysed by gas chromatography fitted with a flame ionisation detector (GC–FID) and coupled to mass spectrometry (GC–MS). Thirty one components were identified, representing around 75.7% of total oil. The major components were β-eudesmol (13.16%), α-eudesmol (13.05%), γ-eudesmol (7.54%), guaiol (5.12%), caryophyllene oxide (4.18%) and β-bisabolene (4.10%). The essential oil showed antimicrobial activity against Gram-positive bacteria and yeast with the MIC values between 25.0 and 100 μg/mL. The highest antiproliferative activity was observed for the oil against MCF-7 (breast, TGI = 12.8 μg/mL), NCI-H460 (lung, TGI = 13.0 μg/mL) and PC-3 (prostate, TGI = 9.6 μg/mL) cell lines, while against no cancer cell line HaCat (keratinocyte) the TGI was 38.8 μg/mL. The oil exhibited a small antioxidant activity assessed through ORAC-FL assay (517 μmol TE/g). This is the first report regarding the chemical composition and bioactivity of A. brevipes essential oil. |
| |
| Keywords: | Anaxagorea brevipes Annonaceae essential oil bioactivity |
|
|
