A rapid,mild, and efficient method for C-5 iodination/thiocyanation of 2-aminothiazoles |
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| Authors: | Madhav J Hebade Rahul D Kamble Shrikant V Hese Pratima P Mogle Ajay N Ambhore Shuddhodan N Kadam |
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| Institution: | School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded, India |
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| Abstract: | An efficient, green, rapid multitasking protocol for the selective C-5 substitution of 2-aminothiazole using iodic acid and aqueous PEG-400 was developed. The method found suitable for C-5 substitution i.e. iodination and thiocyanation of 2-amino thiazole using iodine and ammonium thiocyanate respectively. Iodic acid was found to be a good oxidant and aqueous PEG-400 as green reaction solvent. |
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| Keywords: | Aq PEG-400 iodination thiocyanation iodic acid 2-aminothiazole |
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