Non-alkaloids extract from Stemona sessilifolia enhances the activity of chemotherapeutic agents through P-glycoprotein-mediated multidrug-resistant cancer cells |
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| Authors: | Lu Han Yang-Mei Ma Li An Qiao Zhang Chang-Li Wang |
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| Institution: | 1. Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang 110840, China;2. Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China;3. Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | One of the major impediments to the successful treatment of cancer is the development of resistant cancer cells, which could cause multidrug resistance (MDR), and overexpression of ABCB1/P-glycoprotein (P-gp) is one of the most common causes of MDR in cancer cells. Recently, natural products or plant-derived chemicals have been investigated more and more widely as potential multidrug-resistant (MDR) reversing agents. The current study demonstrated for the first time that non-alkaloids extract from Stemona sessilifolia significantly reversed the resistance of chemotherapeutic agents, adriamycin, paclitaxel and vincristine to MCF-7/ADR cells compared with MCF-7/S cells in a dose-dependent manner. The results obtained from these studies indicated that the non-alkaloids extract from S. sessilifolia plays an important role in reversing MDR of cancer as a P-gp modulator in vitro and may be effective in the treatment of multidrug-resistant cancers. |
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| Keywords: | Stemona sessilifolia non-alkaloids extract multidrug resistance P-gp MCF-7/ADR cells cancer |
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