A new macrolactin antibiotic from deep sea-derived bacteria Bacillus subtilis B5 |
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| Authors: | Wei Li Xi-Xiang Tang Xia Yan Zhen Wu Zhi-Wei Yi Mei-Juan Fang |
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| Institution: | 1. School of Life Science and Biopharmaceutical, Shenyang Pharmaceutical University, Shenyang, China;2. Key Laboratory of Marine Biogenetic Resources, The Third Institute of Oceanography, The State Oceanic Administration, Xiamen, China;3. South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Xiamen, China;4. School of Pharmaceutical Sciences, Xiamen University, Xiamen, China |
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| Abstract: | A new macrolactin derivate, 7-O-2′E-butenoyl macrolactin A (1), together with three known macrolactin compounds, macrolactin A (2), 7-O-malonyl macrolactin A (3) and 7-O-succinyl macrolactin A (4), was isolated from the bacterial strain Bacillus subtilis B5, which was isolated from the 3000 m deep sea sediment of the Southwest Pacific Ocean. The structures of the new compounds were assigned by spectroscopic methods including 1-D/2-D NMR and MS analysis techniques. Compounds 1 and 2 demonstrated antifungal activities against tea pathogenic fungi Pestalotiopsis theae and Colletotrichum gloeosporioides. |
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| Keywords: | Bacillus subtilis B5 7-O-2′E-butenoyl macrolactin A antifungal activity |
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