Hepatoprotective phenylethanoid glycosides from Cirsium setosum |
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| Authors: | Qinge Ma Yongming Guo Baomin Luo Wenmin Liu Rongrui Wei Chunxia Yang |
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| Affiliation: | 1. Department of Graduate Students, College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, Chinamaqinge2006@163.com;3. Department of Graduate Students, College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China;4. Department of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing, China |
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| Abstract: | Two new phenylethanoid glycosides, namely β-D-glucopyranoside, 1″-O-(7S)-7-(3-methoxyl-4-hydroxyphenyl)-7-methoxyethyl-3″-α-L-rhamnopyranosyl-4″-[(8E)-7-(3-methoxyl-4-hydroxyphenyl)-8-propenoate] (1) and β-D-glucopyranoside, 1″-O-(7S)-7-(3-methoxyl-4-hydroxyphenyl)-7-methoxyethyl-3″-α-L-rhamnopyranosyl-4″-[(8E)-7-(4-hydroxyphenyl)-8-propenoate] (2), together with six phenylethanoid glycosides were isolated from Cirsium setosum. Their structures were elucidated by their spectroscopic data and references. Compounds 2, 4, 5, 7 and 8 (10 μM) exhibited moderate hepatoprotective activities. Compounds (3–8) were obtained from this plant for the first time. |
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| Keywords: | Cirsium setosum phenylethanoid glycoside hepatoprotective activity |
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