New naphthopyrones from marine-derived fungus Aspergillus niger 2HL-M-8 and their in vitro antiproliferative activity |
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| Authors: | Da-Hong Li Tong Han Li-Ping Guan Jiao Bai Nan Zhao Zhan-Lin Li |
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| Affiliation: | 1. Key Laboratory of Structure-Based Drug Design &2. Discovery, Ministry of Education and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China |
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| Abstract: | A new cytotoxic dimeric naphthopyrone, aurasperone H (1), together with eight related known polyketides (2–9) was isolated from a marine-derived fungus Aspergillus niger 2HL-M-8. The structure of new compound 1 was elucidated on the basis of its spectroscopic data (1D, 2D NMR and CD). Compound 1 exhibited moderate inhibitory activity against the human lung adenocarcinoma A549 and the human leukaemia HL-60 cell lines. Compound 5 displayed significant in vitro antiproliferative activity against HL-60 cell line with an IC50 value of 0.8 μM. |
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| Keywords: | Aspergillus niger dimeric naphthopyrones antiproliferative activity |
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