A new furan derivative from an endophytic Aspergillus flavus of Cephalotaxus fortunei |
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| Authors: | Yang-Min Ma Cong-Cong Ma Ting Li Jun Wang |
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| Institution: | 1. Key Laboratory of Auxiliary Chemistry &2. Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science &3. Technology, Xi'an 710021, P.R. Chinamym63@sina.com;5. Technology, Xi'an 710021, P.R. China |
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| Abstract: | A new furan derivative named 5-acetoxymethylfuran-3-carboxylic acid (2), together with a known furan compound, 5-hydroxymethylfuran-3-carboxylic acid (1), were isolated from the fermentation of Aspergillus flavus, endophytic fungi in Cephalotaxus fortunei. The structures of 1 and 2 were elucidated by NMR, IR, UV and MS data, as well as compared with literature data. The compounds 1 and 2 exhibited potent antibacterial activity against Staphylococcus aureus with MIC values of 31.3 and 15.6 μg/mL, respectively. The compound 2 showed moderate antioxidant activity. |
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| Keywords: | furan derivative 5-acetoxymethylfuran-3-carboxylic acid Aspergillus flavus Cephalotaxus fortunei |
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