Synthesis,characterization, and antitumor evaluation of 4-aminoximidofurazan derivatives |
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| Authors: | Ewies F Ewies Marwa El-Hussieny Naglaa F El-Sayed Mamdouh M Ali Abeer E Mahmoud |
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| Institution: | 1. Department of Organometallic and Organometalloid Chemistry, National Research Centre, Dokki, Giza, Egyptef.ewies@nrc.sci.eg ewiesfawzy@yahoo.com;3. Department of Organometallic and Organometalloid Chemistry, National Research Centre, Dokki, Giza, Egypt;4. Biochemistry Department, National Research Centre, Dokki, Giza, Egypt |
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| Abstract: | Reactions of 3-amino-4-aminoximidofurazan (AAOF) with Wittig–Horner reagents, trialkylphosphites, trisdialkylaminophosphines as well as the thiating Lawesson and Japanese reagents were studied. Elemental analysis and spectroscopic measurements were in good accord with the structures postulated for the new products. The antitumor activities of certain selected new compounds were screened, in vitro, against a panel of five (liver; HepG2; breast; MCF-7; lung; A549; colon; HCT116; and prostate PC3) human solid tumor cell lines. |
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| Keywords: | 3-Amino-4-aminoximidofurazan (AAOF) phosphorus reagents reactions spectroscopic measurements antitumor activities |
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