Sesquiterpene-neolignans from Manglietia hookeri |
| |
| Authors: | Xiaoqing Hu Xianjin Sui Yijing Wang Haibo Wu Feiran Zhang |
| |
| Affiliation: | 1. College of Life and Environmental Sciences, Minzu University of China, Beijing, P.R. China;2. Beijing Engineering Research Center of Food Environment and Health, Minzu University of China, Beijing, P.R. China |
| |
| Abstract: | The comet assay-guided fractionation of the twigs of Manglietia hookeri resulted in the isolation of three sesquiterpene-neolignans, including a new one 5-allyl-2-(4-allyl-phenoxy)-3-[7-(1-hydroxy-1-methyl-ethyl)-1, 4a-dimethyl-decahydro-naphthalen-1-yloxy]-phenol (1), and eudesobovatol A (2) and eudesobovatol B (3), together with three lignans, obovatol (4), honokiol (5) and magnolol (6). Their structures were elucidated on the basis of spectral analysis and by comparison with related literature data. Compounds 1, 4–6 showed a protective effect on UV inductive DNA damage in mice lymphocyte cells, while compound 1 indicated the smallest Olive Tail Moment 7.34 ± 2.09 at 6 × 10?6 μM. |
| |
| Keywords: | Magnoliaceae Manglietia hookeri sesquiterpene-neolignans comet assay |
|
|
