Bioactivity-guided isolation of new antiproliferative compounds from Juniperus foetidissima Willd. |
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| Authors: | Mahmood Rafieian-kopaei Ibrahim Suleimani dehkordi Ardeshir Shokrollahi Mahmoud Aghaei Ayatollahi Syed Majid |
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| Affiliation: | 1. Department of Pharmacology, Shahrekord University of Medical Sciences, Shahrekord, Iran;2. Chemistry Department, Yasouj University, Yasouj, Iran;3. Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;4. Phytochemistry Research Center and School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
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| Abstract: | Based on a literature survey on cytotoxic medicinal plants, Juniper species were identified as interesting source of antitumor compounds. Using bioassay-guided fractionation against Caov-4 cancer cells on acetone extract of leaves and branchlets of Juniperus foetidissima led to the isolation of a new 3H-benzofuaran-2-one: 4-methyl-3-methoxy-3H-benzofuaran-2-one (1), a new sesquiterpene: 4,9(α)-dihydroxy-nardosin-6-en (2) and an already known labdane-type diterpene: 15-hydroxy-8(17),13(E)-labdadiene-19-carboxilic acid (3). Compounds 1–3 exhibited cytotoxic effects, with moderate cytotoxicity against the EJ-138 bladder and CAOV-4 ovary cancer cell lines. |
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| Keywords: | Cupressaceae Juniperus foetidissima cytotoxicity ovary cancer cell bladder cancer cell |
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