New analogues of brefeldin A from sediment-derived fungus Penicillium sp. DT-F29 |
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Authors: | Zhi-Fei Hu Le-Le Qin Yu Liu |
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Affiliation: | 1. Institute of Marine Biology &2. Natural Products, Ocean College, Zhejiang Univesity, Hangzhou, China;3. State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, China |
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Abstract: | Four new analogues of brefeldin A named 7, 7-dimethoxybrefeldin C (3), 6β-hydroxybrefeldin C (4), 4-epi-15-epi-brefeldin A (5), 4-epi-8α-hydroxy-15-epi-brefeldin C (6), together with four known analogues (1, 7?9) were isolated from a fermentation of the sediment-derived fungus Penicillium sp. DT-F29. The structures of these compounds were elucidated on the basis of extensive spectroscopic and chemical methods. In the bioactivity assays, only compounds 1 and 8 showed significant inhibitory activities against human lung adenocarcinoma cell. In addition, compound 1 was first reported for the potent ability to reactivate latent HIV with EC50 value of 0.03 μM. |
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Keywords: | Sediment-derived fungus Penicillium brefeldin A antitumour latent HIV |
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