New stigmastane type of steroidal glycosides from the roots of Vernonia cumingiana |
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| Authors: | Guo-Xu Ma Wei Feng Zhong-Hao Sun Peng-Fei Li Nai-Liang Zhu Jun-Shan Yang |
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| Institution: | 1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P. R. China;2. Pharmacology Laboratory of Traditional Chinese Medicine, Hebei University of Chinese Medicine, Shijiazhuang, P. R. China |
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| Abstract: | Two new stigmastane type of steroidal glycosides, vernoniacums A and B (1 and 2), with a △7,9(11) steroidal core were isolated from the roots of Vernonia cumingiana. Their structures were elucidated based on various spectroscopic techniques, including IR, HR-FAB-MS, and 1D and 2D NMR. Both compounds were evaluated for their cytotoxicity against HeLa and HCT-8 cells, and compound 1 showed mild activity against the tested cell lines with IC50 values of 15.8 and 35.7 pounds were evaluated for their cytotoxicity against HeLa and HCT-8 cells, and compound 1 showed mild activity against the tested cell lines with IC50 values of 15.8 and 35.7 μM, respectively. |
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| Keywords: | Cytotoxic activity steroidal glycoside vernonia cumingiana |
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