Trichocitrin,a new fusicoccane diterpene from the marine brown alga-endophytic fungus Trichoderma citrinoviride cf-27 |
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Authors: | Xiao-Rui Liang Feng-Ping Miao Yin-Ping Song |
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Institution: | 1. Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, China;2. Department of Basic Sciences, Naval Aeronautical and Astronautical University, Yantai, China;3. University of Chinese Academy of Sciences, Beijing, China |
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Abstract: | One new diterpene, trichocitrin (1), and four known secondary metabolites, nafuredin (2), 5-hydroxy-2,3-dimethyl-7-methoxychromone (3), 24-methylenecycloartanol (4) and citrostadienol (5), were isolated from the culture of marine brown alga-endophytic Trichoderma citrinoviride cf-27. Trichocitrin (1) represents the first Trichoderma-derived and furan-bearing fusicoccane diterpene, and its structure and relative configuration were identified by analysis of 1D/2D NMR and mass spectroscopic data. Compounds 1 and 2 exhibited 8.0- and 9.5-mm inhibition zones, respectively, against Escherichia coli at 20 μg/disc and 54.1 and 36.7% growth inhibition, respectively, of Prorocentrum donghaiense at 80 μg/mL. |
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Keywords: | Trichoderma citrinoviride diterpene trichocitrin nafuredin |
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