Synthesis,Crystal Structures,Fluorescence and Xanthine Oxidase Inhibitory of Sulfur-Containing Pyrazole Derivatives Incorporated with Oxadiazole and Triazole |
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| Authors: | De-Qiang Qi Jin-Zong You Guang-Hui Yang Xue-Jie Wang Yi-Ping Zhang |
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| Affiliation: | 1. College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang, PR China;2. School of Science and Technology, Zhejiang International Studies University, Hangzhou, Zhejiang, PR China;3. School of Science and Technology, Zhejiang International Studies University, Hangzhou, Zhejiang, PR China |
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| Abstract: | Some sulfur-containing pyrazole derivatives incorporated with 1,3,4-oxadiazole and 1,2,4-triazole were designed and synthesized. All the compounds were fully characterized by IR, 1H NMR, 13C NMR and elemental analyses. Two crystal structures were determined by single crystal X-ray diffraction analyses. The fluorescence properties were investigated in DMSO solution. In addition, the in vitro xanthine oxidase (XO) inhibitory activity were evaluated, and the results showed that one compound displayed moderate XO inhibitory activity. |
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| Keywords: | Crystal structures pyrazole 1,3,4-oxadiazole 1,2,4-triazole fluorescence xanthine oxidase |
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