Two new diacetylene glycosides: bhutkesoside A and B from the roots of Ligusticopsis wallichiana |
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| Authors: | Bibek Adhikari Khem Raj Joshi Takashi Watanabe |
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| Institution: | 1. Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan;2. Program for Leading Graduate Schools, HIGO Program, Kumamoto University, Kumamoto, Japan |
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| Abstract: | Two new diacetylene glycosides: bhutkesoside A (1) and B (2), along with 10 known compounds, i.e. falcarindiol (3), chlorogenic acid (4), 5-O-p-coumaroyl-quinic acid (5), 3,5-di-O-caffeoyl-quinic acid (6), 4-hydroxy-7-methoxy-phenylethanol (7), ferulic acid (8), dehydrodiconiferyl alcohol-4-O-β-d-glucopyranoside (9), 5,7-dihydroxy-2-methylchromone-7-O-rutinoside (10), schumanniofioside B (11) and marmesinin (12) were isolated from the roots of Ligusticopsis wallichiana (DC) Pimenov & Kljuykov (Apiaceae), commonly known as ‘Bhutkesh’ in Nepal. The structures were determined on the basis of spectroscopic data. Compounds 4 and 6 showed potent antioxidant activity on DPPH free radical scavenging assay. |
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| Keywords: | Ligusticopsis wallichiana Apiaceae Bhutkesh bhutkesoside A bhutkesoside B |
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