N-isocyaniminotriphenylphosphorane (Ph3PNNC) as an efficient reagent for the synthesis of ferrocene-containing 1,3,4-oxadiazole derivatives |
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| Authors: | Ali Ramazani Nadia Fattahi Mona Ashtari Aram Rezaei |
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| Affiliation: | 1. Department of Chemistry, University of Zanjan, Zanjan, Iranaliramazani@gmail.com;3. Department of Chemistry, University of Zanjan, Zanjan, Iran |
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| Abstract: | Reaction of N-isocyaniminotriphenylphosphorane (Ph3PNNC) with an aromatic aldehyde in the presence of ferrocene carboxylic acid and a secondary amine proceeds smoothly at room temperature under neutral conditions to afford sterically congested ferrocene-containing 1,3,4-oxadiazole derivatives in high yields. The reaction progresses smoothly and clearly under mild conditions and no side reactions were observed. |
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| Keywords: | N-isocyaniminotriphenylphosphorane (Ph3PNNC) aromatic aldehyde ferrocene carboxylic acid secondary amine 1,3,4-oxadiazole aza-Wittig reaction |
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