Lasiodiplodins from mangrove endophytic fungus Lasiodiplodia sp. 318# |
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| Authors: | Jing Li Yanyu Xue Jie Yuan Yongjun Lu Xun Zhu Yongcheng Lin |
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| Institution: | 1. School of Marine Sciences, Sun Yat-sen University, Guangzhou510006, P.R. China;2. School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P.R. China;3. Zhongshan medical college, Sun Yat-sen University, Guanghzhou510800, P.R. China;4. School of Life Sciences, Sun Yat-sen University, Guangzhou510275, P.R. China |
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| Abstract: | Four new lasiodiplodins (1–4), together with three known analogues, have been isolated from a mangrove endophytic fungus, Lasiodiplodia sp. 318#. Their structures were elucidated by spectroscopic techniques. Cytotoxic activities of compounds 1–7 were evaluated in vitro against human cancer lines THP1, MDA-MB-435, A549, HepG2 and HCT-116. Compound 4 exhibited moderate cytotoxic activities. |
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| Keywords: | endophytic fungus lasiodiplodins cytotoxic activity |
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