Organocatalytic clean synthesis of densely functionalized 4H-pyrans by bifunctional tetraethylammonium 2-(carbamoyl)benzoate using ball milling technique under mild conditions |
| |
| Authors: | Mohammad G Dekamin Mohammad Alikhani Shahrzad Javanshir |
| |
| Institution: | 1. Pharmaceutical and Biologically-Active Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iranmdekamin@iust.ac.ir;3. Pharmaceutical and Biologically-Active Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran |
| |
| Abstract: | A green and simple method has been developed for efficient preparation of diverse annulated 2-amino-3-cyano-4H-pyran derivatives in the presence of a low loading of tetraethylammonium 2-(carbamoyl)benzoate (TEACB), as a bifunctional organocatalyst, under solvent-free conditions using the ball milling technique. This procedure is a clean, transition-metal-free, and environmentally friendly approach that offers many advantages including short reaction times, high to quantitative yields, low cost, and straightforward work-up. |
| |
| Keywords: | Tetraethylammonium 2-(carbamoyl)benzoate organocatalysis green chemistry 4H-pyrans multicomponent reactions |
|
|
