Extraction,identification and antimicrobial activity of a new furanone,grifolaone A,from Grifola frondosa |
| |
Authors: | Xiaoyun He Xuezhu Du Xiangyun Zang Lili Dong Zijian Gu Liping Cao |
| |
Institution: | 1. College of Life Science, Hubei University, Wuhan, China;2. Fujian-Taiwan Joint Centre for Ecological Control of Crop Pests, Fuzhou, China;3. Key Laboratory of Biopesticide and Chemical Biology, Ministry of Education, Fuzhou, China;4. National Engineering Research Center of Juncao Technology, Fuzhou, China;5. Fujian-Taiwan Joint Centre for Ecological Control of Crop Pests, Fuzhou, China |
| |
Abstract: | A furanone (1), (S)-methyl 2-(2-hydroxy-3,4-dimethyl-5-oxo-2,5-dihydrofuran-2-yl)acetate, was isolated from the edible mushroom Grifola frondosa. Mass spectrometry and NMR analyses were used to elucidate the structure of this compound, and its absolute configuration was determined using circular dichroism spectroscopy. Compound 1 exhibited specific antifungal activity against the plant pathogens, Fusarium oxysporum, Gibberella zeae and Piricularia oryzae and the opportunistic human pathogen, Pseudallescheria boydii, resulting in minimum inhibitory concentration values of 2.5, 2.5, 1.25 and 0.15 μg/mL, respectively. In contrast, the furanone showed only weak activity towards Aspergillus spp., Candida albicans and several other fungal strains tested as well as no appreciable antibacterial activity. |
| |
Keywords: | Grifola frondosa furanone antifungal activity |
|
|