A new flavan from the Drynaria bonii H. Christ rhizomes |
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Authors: | Pham Thi Nhat Trinh Mai Dinh Tri Dang Chi Hien Nguyen Huu An Phan Nhat Minh Pham Ngoc An |
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Institution: | 1. Tien Giang University, National Highway No. 1, Chau Thanh, Tien Giang, Vietnam;2. Institute of Chemical Technology, Vietnam Academy of Science and Technology, 01 Mac Dinh Chi, Dist. 1, Ho Chi Minh City, Vietnam |
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Abstract: | In Vietnam, the medicinal plant Drynaria bonii H. Christ is used for the treatment of osteoporosis, bone fractures, and stimulate the growth of hair, treat tinnitus (Ho 2002; Loi 2004). In this article, experiments were designed to investigate the proliferation activity of ethanol, n-hexane, chloroform, ethyl acetate and methanol extracts from D. bonii rhizomes on MG-63 human osteoblast-like cells. The results showed that methanol and hexane extracts had the ability to proliferate MG-63 cells at the concentration varying from 0.1 to 0.01 μg/mL. In particular, at the concentration of 0.01 μg/mL, hexane and methanol extracts illustrated the highest proliferation ratio with 9.31% and 6.16%, respectively. By column chromatography, a new compound named drynaether A (1) and five known compounds uracil (2), 4′-hydroxy-7-methoxyflavan (3), kaempferol (4), indole-3-carboxylic acid (5) and protocatechuic acid (6) were isolated and identified from the methanol extract. |
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Keywords: | Drynaria bonii MG-63 cell drynaether A |
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