首页 | 本学科首页   官方微博 | 高级检索  
     检索      


A study of host-guest complexation between amodiaquine and native cyclodextrin. Characterization in solid state and its in-vitro anticancer activity
Authors:Moorthiraman Murugan  Krishnamoorthy Sivakumar
Institution:1. Research and Development Centre, Bharathiar University, Coimbatore, India;2. Department of Chemistry, IFET College of Engineering, Villupuram, India;3. Department of Chemistry, SCSVMV University, Kanchipuram, India
Abstract:Amodiaquine (AQ) has been used widely as an antimalarial drug. Amodiaquine is a mannich base 4-amino quinolone with a mode of action similar to that of chloroquine. The inclusion complex of AQ with β-Cyclodextrin (β-CD) in solution phase is studied from the ground and excited state with UV-Visible and fluorescence spectroscopy, respectively. A binding constant and stoichiometric ratio between AQ and β-CD are calculated by BH equation. The solid complexes are prepared by physical method (PM), kneading method (KM) and co-precipitation method (CP). The solid complex is characterized by Fourier transform infrared spectroscopy, scanning electron microscopy and powder X-ray diffraction. The CP method gives the solid product with a better yield than that of physical mixture and KM products. The orientation and structure of the complex are proposed based on the analysis of Patch-Dock server. The anticancer activity also performed for pure AQ and their complex with β-CD. It is clearly shown that an improvement of anticancer activity of AQ while forming complex with β-CD. The solid inclusion complex behaves as the better anticancer ability than AQ alone.
Keywords:Amodiaquine  β-cyclodextrin  inclusion complex  XRD  Patch-Dock server  in vitro anticancer activity
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号