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A new lumazine peptide penilumamide E from the fungus Aspergillus terreus |
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| Authors: | Boonyanoot Chaiyosang Kwanjai Kanokmedhakul Jaursup Boonmak Sujittra Youngme Veerapol Kukongviriyapan Kasem Soytong |
| Institution: | 1. Faculty of Science, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Natural Products Research Unit, Khon Kaen University, Khon Kaen, Thailand;2. Faculty of Science, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Material Chemistry Research Center, Khon Kaen University, Khon Kaen, Thailand;3. Faculty of Medicine, Department of Pharmacology, Khon Kaen University, Khon Kaen, Thailand;4. Faculty of Agricultural Technology, Department of Plant Production Technology, King Mongkut’s Institute of Technology Ladkrabang, Bangkok, Thailand |
| Abstract: | A new rare lumazine peptide, penilumamide E (1), together with 13 known compounds (2–14) were isolated from the fungus Aspergillus terreus. Their structures were identified by spectroscopic techniques. The relative configuration of 1 was confirmed by single-crystal X-ray diffraction analysis. Compound 10 exhibited antimalarial activity against Plasmodium falciparum with IC50 values of 2.83 μg/mL. Compounds 4 and 6 showed weak cytotoxicity against cholangiocarcinoma (CCA) cell lines. In addition, 4 and 11 exhibited weak cytotoxicity against human hepatoma cell line. |
| Keywords: | Aspergillus terreus lumazine peptide penilumamide E epi-aszonalenin A butyrolactone antimalarial |