|
|||||
|
|
Synthesis of poly(ether esters) from reaction of alpha-cyano-4-hydroxycinnamic acid and group IVB metallocenes |
|
| Authors: | Charles E Carraher Jr Michael R Roner Marian Ayoub Ryan Crichton Alisa Moric-Johnson Lindsey Miller |
| Institution: | 1. Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FLcarraher@fau.edu;3. Department of Biology, University of Texas Arlington, Arlington, TX;4. Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL |
| Abstract: | Poly(ether esters) are rapidly synthesized in moderate yield employing the interfacial polycondensation reaction system from the reaction of alpha-cyano-4-hydroxycinnamic acid and Group IVB metallocenes. The products are high polymers. Infrared spectroscopy shows the formation of new bands derived from the M-O and M-O(CO) linkages. It also shows that the products exist as alternating M-O and M-O(CO) linkages. The products show outstanding inhibition of a variety of cancer cell lines including two pancreatic cancer cell lines. EC50 values for the polymers are in the nanogram/mL range. The ability to inhibit the cancer cell lines is generally Hf>Zr>Ti. Thus, future synthesis and testing might consider using compounds containing hafnocene and zirconocene in addition to the titanocene moiety. |
| Keywords: | Group IVB-containing polymers metallocene-containing polymers hafnocene polymer zirconocene polymer titanocene polymers pancreatic cancer inhibition of cancer cell lines interfacial polymerization |