Chemical composition and biological activities of essential oil from Filifolium sibiricum (L.) Kitam |
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Authors: | Shanshan Liang Qing Wei Juan Xue Yichun Sun Zhili Chen Haixue Kuang |
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Affiliation: | Key Laboratory of Chinese Materia Medica(Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin, China |
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Abstract: | The essential oil from Filifolium sibiricum (L.) Kitam were extracted using hydrodistillation and GC-MS was used to analyse the essential oil. The main components were espatulenol (8.55%), geranyl acetate (8.03%), caryophyllene oxide (5.47%), calamenene (4.79%), geraniol (4.28%), calamenene (4.53%), geraniol (4.06%), cedrene epoxide (3.23%), myrtenol (3.18%), transgeranylgeranio (3.13%), etc. The essential oil showed intensive inhibitory effects against MCF-7 with IC50 level of 0.78 mg/mL, HepG-2 with IC50 level of 0.44 mg/mL, SKOV-3 with IC50 level of 0.27 mg/mL, BGC-823 with IC50 level of 0.34 mg/mL. In the antibacterial test, the essential oil showed the significant antibacterial activities. The MIC and MBC values were 5.20 and 5.20 mg/mL against Staphylococcus aureus. |
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Keywords: | Filifolium sibiricum (L.) Kitam essential oil GCMS cytotoxicity antibacterial activity |
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