Two new sesquiterpene lactones from the fruits of Illicium jiadifengpi |
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Authors: | Jifeng Liu Feiyan Liu Nenling Zhang Yafeng Wang Lijia Yang Yuefeng Bi |
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Affiliation: | 1. School of Pharmaceutical Science, Zhengzhou University, Ke Xue Da Dao 100, Zhengzhou 450001, People's Republic of Chinaliujf2009y@126.com 2009liumq@163.com;3. School of Pharmaceutical Science, Zhengzhou University, Ke Xue Da Dao 100, Zhengzhou 450001, People's Republic of China;4. School of Pharmacy, Guiyang Medical University, Guiyang 550004, People's Republic of China;5. Henan Key Laboratory for Pharmacology of Liver Disease, Academy of Medical and Pharmaceutical Science, Zhengzhou University, 40 Daxue Road, Zhengzhou 450052, People's Republic of China |
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Abstract: | Two new seco-prezizaane-type sesquiterpenes, 3,4-dehydroneomajucin (1) and 1,2,3,4-tetradehydroneomajucin (2), were isolated from the fruits of Illicium jiadifengpi. The structure of these compounds was determined using 1D and 2D NMR and ESI-MS. The isolates were evaluated for their anti-hepatitis B virus activities on the Hep G2.2.15 cell line. The inhibitory rates of compounds 1 and 2 on the HBeAg and HBsAg expression were 30.08 ± 3.09% and 11.43 ± 1.92% at a concentrations of 68.00 μM and 7.88 ± 1.21% and 16.96 ± 4.24% at a concentration of 68.50 μM, respectively. |
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Keywords: | Illicium jiadifengpi sesquiterpene lactones anti-HBV activity |
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