L-proline derivatives based on a calix[4]arene scaffold as chiral organocatalysts for the direct asymmetric aldol reaction in water |
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| Authors: | Mehmet Aktas Arzu Uyanik Serkan Eymur |
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| Institution: | 1. Department of Chemistry, Selcuk University, Konya, Turkey;2. Department of Energy Systems Engineering, Giresun University, Giresun, Turkey |
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| Abstract: | AbstractA new series of water-compatible proline catalysts (4–6) derived from calixarene bearing a hydrophobic nature have been synthesised. It was found that the compound 4 was a highly efficient organocatalyst for aldol reactions occurred in the water. Under optimised reaction conditions, high yields (up to 82%), good enantioselectivities (ee up to 81%) and high diastereoselectivities (dr up to 91:9) were obtained. |
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| Keywords: | Calix[4]arene organocatalysis aldol enantioselective |
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