A new furanosteroid from Talaromyces sp. lgt-4, a fungal endophyte isolated from Tripterygium wilfordii |
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| Authors: | Kang-Kang Zhi Shuang-Yan Zhou Shuo Li Fei Zhang |
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| Institution: | 1. School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, P.R. China;2. The Provincial Education Key Laboratory of Screening, Evaluation and Advanced Processing of Traditional Chinese Medicine and Tibetan Medicine, School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, P.R. China;3. Department of Chemistry, Lanzhou University, Lanzhou, P.R. China;4. School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, P.R. China |
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| Abstract: | Wortmannolol (1), a new furanosteroid, along with five known compounds, wortmannolone (2), ergosterol (3), p-hydroxyphenyl ethanol (4), trans-6-dodecene (5), (2Z, 4E) -5-(8-hydroxy-1,5-dimethyl-3-oxo-6-oxabicyclo 3.2.1] octan-8-yl) -3-methylpenta-2,4-dienoic acid (6) were isolated from a fungal endophyte Talaromyces sp. lgt-4. Their structures were elucidated by IR, MS, 1D and 2D NMR spectra. Compound 1 show weak monoamine oxidase inhibitory activity. |
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| Keywords: | Furanosteroid Tripterygium wilfordii endophyte Talaromyces |
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