Pyrrolizidine alkaloids from Solenanthus lanatus DC. with acetylcholinesterase inhibitory activity |
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| Authors: | Houari Benamar Lamberto Tomassini Alessandro Venditti Abderrazak Marouf Malika Bennaceur Marcello Nicoletti |
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| Institution: | 1. Laboratory of Biochemistry and Natural Products, Department of Biology, Faculty of Natural Sciences and Life, University of Oran 1 Ahmed Benbella, Oran, Algeria;2. Department of Biology, Faculty of Natural Sciences and Life, University of Mostaganem Abdelhamid Ibn Badis, Mostaganem, Algeriahouaribenamar@hotmail.com;4. Department of Environmental Biology, University “Sapienza”, Rome, Italy;5. Institute of Science and Technology, Department of Natural Sciences and Life, Ctr Univ Naama, Naama, Algeria;6. Laboratory of Research in Arid Areas, Faculty of Biological Sciences, University of Science and Technology Houari Boumediene, Algiers, Algeria |
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| Abstract: | The whole plant ethanolic extract of Solenanthus lanatus was used for the isolation of acetylcholinesterase inhibitors. A new pyrrolizidine alkaloid, 7-O-angeloylechinatine N-oxide, 1, was isolated together with three known compounds of the same class (3′-O-acetylheliosupine N-oxide, 2, heliosupine N-oxide, 3, and heliosupine, 4), by bioassay-guided approach. Their structures were elucidated by spectroscopic methods. All the isolated compounds showed inhibition activity against the AChE, with IC50 0.53–0.60 mM. |
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| Keywords: | Boraginaceae Solenantus lanatus pyrrolizidine alkaloids 7-O-angeloylechinatine N-oxide anti-AChE activity |
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