| 五种西佛碱配合物对金黄色葡萄球菌代谢抑制的热化学研究 |
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| 引用本文： | 刘义,冯英,谢昌礼,屈松生,冯长建,乐芝凤,张香才,吴自慎.五种西佛碱配合物对金黄色葡萄球菌代谢抑制的热化学研究[J].无机化学学报,1996,12(2):150-155. |
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| 作者姓名： | 刘义 冯英 谢昌礼 屈松生 冯长建 乐芝凤 张香才 吴自慎 |
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| 作者单位： | 武汉大学化学系 武汉430072
(刘义，冯英，谢昌礼，屈松生)，华中师范大学化学系 武汉430070
(冯长建，乐芝凤，张香才)，华中师范大学化学系 武汉430070(吴自慎) |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 用微量热法研究了五种西佛碱金属配合物对金黄色葡萄球菌代谢抑制作用。发现不同西佛碱金属配合物对金黄色葡萄球菌的作用效果不同 ,其药效为 :Cu( ) - L>Cu( ) - OVG>Co( ) - L>Zn( ) - OVG>Zn( ) - L,半抑制浓度 HIC依次增大。不同金属配合物作用下 ,金黄色葡萄球菌代谢热谱有所不同 ,说明不同西佛碱金属配合物对金黄色葡萄球菌作用的方式不同。
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| 关 键 词： | 西佛碱金属配合物 金黄色葡萄球菌 微量热法 热化学 |
| 收稿时间： | 7/5/1995 12:00:00 AM |
THERMOCHEMICAL STUDY ON THE INHIBITION OF SCHIFF BASE METAL COMPLEXES TO THE METABOLISM OF S.AUREUS |
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| Liu Yi,Feng Ying,Xie Changli,Qu Songsheng,Feng Changjian,Yue Zhifeng,Zhang Xiangcai and Wu Zishen.THERMOCHEMICAL STUDY ON THE INHIBITION OF SCHIFF BASE METAL COMPLEXES TO THE METABOLISM OF S.AUREUS[J].Chinese Journal of Inorganic Chemistry,1996,12(2):150-155. |
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| Authors: | Liu Yi Feng Ying Xie Changli Qu Songsheng Feng Changjian Yue Zhifeng Zhang Xiangcai and Wu Zishen |
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| Institution: | Departmentof Chemistry, Wuhan University, Wuhan 430072,Departmentof Chemistry, Wuhan University, Wuhan 430072,Departmentof Chemistry, Wuhan University, Wuhan 430072,Departmentof Chemistry, Wuhan University, Wuhan 430072,Department of Chemistry, Huazhong Normal University, Wuhan 430070,Department of Chemistry, Huazhong Normal University, Wuhan 430070,Department of Chemistry, Huazhong Normal University, Wuhan 430070 and Department of Chemistry, Huazhong Normal University, Wuhan 430070 |
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| Abstract: | In this paper,the inhibition of five kinds of Schiff base metal complexes on S.aureus have been studied by the method of microcalorimetry.The results show thatdifferentkind of complex has differenteffecton S.aureus,itfollowsthe sequence of Cu( ) - L>Cu( ) - OVG >Co( ) - L >Zn( ) - OVG>Zn( ) - L ,their half inhibitory concentrations(HIC) are increased respectively. Under the action of different complexes,their metabolic thermograms are different,the mechanisms of their actionsare also different. |
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| Keywords: | microcalorimetric method Schiff base metal complex S aureus thermochemistry |
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