| Synthesis of New Schizandrin Analogues |
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| 引用本文： | Jun Biao CHANG1*,Jing Xi XIE2 1Henan Institute of Chemistry,Henan Academy of Sciences,Zhengzhou 450002 2Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050. Synthesis of New Schizandrin Analogues[J]. 中国化学快报, 2001, 0(8) |
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| 作者姓名： | Jun Biao CHANG1* Jing Xi XIE2 1Henan Institute of Chemistry Henan Academy of Sciences Zhengzhou 450002 2Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 |
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| 作者单位： | Jun Biao CHANG1*，Jing Xi XIE2 1Henan Institute of Chemistry，Henan Academy of Sciences，Zhengzhou 450002 2Institute of Materia Medica，Chinese Academy of Medical Sciences and Peking Union Medical College，Beijing 100050 |
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| 摘 要： | The lignans are groups of natural products, most of these compounds have various biological activities1. Such as schisandrin possesses extensive significant anti- convulsive activities, particularly regarding cerebral protection and adjustment of the cerebral cortex(s excitement inhibition process. Therefore, it is of interest to synthesize schzandrin and its analogues as potential CNS inhibitory agents. As a part of our drug discovery program for CNS inhibitory agents, we wanted to synthesi…
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Synthesis of New Schizandrin Analogues |
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| Jun Biao CHANG,Jing Xi XIE Henan Institute of Chemistry,Henan Academy of Sciences,Zhengzhou Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing. Synthesis of New Schizandrin Analogues[J]. Chinese Chemical Letters, 2001, 0(8) |
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| Authors: | Jun Biao CHANG Jing Xi XIE Henan Institute of Chemistry Henan Academy of Sciences Zhengzhou Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing |
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| Affiliation: | Jun Biao CHANG1*,Jing Xi XIE2 1Henan Institute of Chemistry,Henan Academy of Sciences,Zhengzhou 450002 2Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050 |
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| Abstract: | Two new lignans with dibenzocycloheptadiene skelectons have been synthesized by intramolecular nonphenolic oxidative coupling and rearrangement. The structures of these products have been identified by MS, UV, IR and NMR spectra. |
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| Keywords: | Schizandrin analogues intramolecular nonphenolic oxidative coupling DDQ. |
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