Achieving Vinylic Selectivity in Mizoroki–Heck Reaction of Cyclic Olefins |
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Authors: | Xiaojin Wu Dr Yunpeng Lu Prof?Dr Hajime Hirao Prof?Dr Jianrong Zhou |
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Institution: | Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Fax: (+65)?67911961 |
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Abstract: | In Heck reactions of cyclic olefins, the products usually have aryl groups that end up at the allylic and/or homoallylic position. We herein report new selectivity that adds aryl groups to the vinylic position. Cyclic olefins of various ring size worked well. The desired isomers were produced by palladium–hydride‐catalyzed isomerization of the initial products. Thus, a specific catalyst must be used so that it can perform two jobs under one set of reaction conditions. |
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Keywords: | arylation Heck reaction isomerization olefins vinylic selectivity |
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