New Cyclodextrin‐Bearing 8‐Hydroxyquinoline Ligands as Multifunctional Molecules |
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| Authors: | Valentina Oliveri Dr. Antonino Puglisi Dr. Maurizio Viale Cinzia Aiello Dr. Carmelo Sgarlata Prof. Graziella Vecchio Dr. James Clarke Dr. John Milton Dr. John Spencer |
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| Affiliation: | 1. Dipartimento di Scienze Chimiche, University of Catania, Viale A. Doria 6, 95125 Catania (Italy);2. Department of Chemistry, School of Life Sciences, University of Sussex, Falmer, Brighton, East Sussex BN1 9QJ (UK);3. IRCCS Azienda Ospedaliera, Universitaria San Martino, IST Istituto Nazionale per la Ricerca sul Cancro, U.O.C. Terapia Immunologia, L.go R. Benzi, 10, 16132 Genova (Italy);4. Oxford Nanopore Technologies, Ltd., Edmund Cartwright House, 4 Robert Robinson Avenue, Oxford Science Park, Oxford, OX4 4GA (UK) |
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| Abstract: | Recent investigations have rekindled interest in 8‐hydroxyquinolines as therapeutic agents for cancer, Alzheimer’s disease, and other neurodegenerative disorders. Three new β‐cyclodextrin conjugates of 8‐hydroxyquinolines and their copper(II) and zinc(II) complexes have been synthesized and characterized spectroscopically. In addition to improving aqueous solubility, due to the presence of the cyclodextrin moiety, the hybrid systems have interesting characteristics including antioxidant activity, and their copper(II) complexes are efficient superoxide dismutase (SOD) mimics. The ligands and their copper(II) complexes show low cytotoxicity, attributed to the presence of the cyclodextrin moiety. These compounds have potential as therapeutic agents in diseases related both to metal dyshomeostasis and oxidative stress. |
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| Keywords: | antioxidants chelating agents copper zinc glycoconjugates |
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