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Enantioselective Aza‐Michael Addition of Imides by Using an Integrated Strategy Involving the Synthesis of a Family of Multifunctional Catalysts,Usage of Multiple Catalysis,and Rational Design of Experiment |
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| Authors: | Mattia Silvi Polyssena Renzi Deborah Rosato Cristiana Margarita Alessio Vecchioni Ivan Bordacchini Diego Morra Alessandro Nicolosi Riccardo Cari Dr. Fabio Sciubba Dr. Daniele M. Scarpino Schietroma Dr. Marco Bella |
| Affiliation: | 1. Department of Chemistry, “Sapienza” University of Roma, P.le Aldo Moro 5, 00185 Roma (Italy);2. Istituto di Chimica Biomolecolare del CNR, P.le Aldo Moro 5, 00185 Roma (Italy) |
| Abstract: | A challenging asymmetric reaction (aza‐Michael addition of imides to enones) has been optimized through an integrated approach involving the synthesis of a family of organocatalysts, multiple catalysis (usage of additives), and finally with rational exploration of the chemical space by the application of the experiment design. |
| Keywords: | asymmetric catalysis aza‐Michael reaction enones imides synthetic methods |