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A New Access Route to Functionalized Cispentacins from Norbornene β‐Amino Acids |
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| Authors: | Dr Loránd Kiss Maria Cherepanova Dr Enikő Forró Prof Ferenc Fülöp |
| Institution: | 1. Institute of Pharmaceutical Chemistry, University of Szeged, 6720 Szeged, E?tv?s u. 6, (Hungary);2. Stereochemistry Research Group of the Hungarian Academy of Sciences, University of Szeged, 6720 Szeged, E?tv?s u. 6, (Hungary) |
| Abstract: | An efficient and simple new stereocontrolled access route to novel disubstituted cispentacin derivatives with multiple stereogenic centers from norbornene β‐lactam has been developed. The synthesis involves olefinic bond functionalization by dihydroxylation followed by oxidative ring cleavage and transformation of the dialdehyde intermediate through a Wittig reaction. |
| Keywords: | cyclopentanes enzymatic resolution oxidation stereochemistry Wittig reactions |