Salimabromide: Unexpected Chemistry from the Obligate Marine Myxobacterium Enhygromxya salina |
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| Authors: | Stephan Felder Dr. Sandra Dreisigacker Dr. Stefan Kehraus Edith Neu Prof. Dr. Gabriele Bierbaum Patrick R. Wright Prof. Dr. Dirk Menche Dr. Till F. Schäberle Prof. Dr. Gabriele M. König |
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| Affiliation: | 1. Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn (Germany), Fax: (+49)?228‐733250;2. Kekulé‐Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard‐Domagk‐Strasse 1, 53121 Bonn (Germany);3. Institute of Medical Microbiology, Immunology and Parasitology, University of Bonn, Sigmund‐Freud‐Strasse 25, 53105 Bonn (Germany) |
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| Abstract: | Marine myxobacteria (Enhygromyxa, Plesiocystis, Pseudoenhygromyxa, Haliangium) are phylogenetically distant from their terrestrial counterparts. Salimabromide is the first natural product from the Plesiocystis/Enhygromyxa clade of obligatory marine myxobacteria. Salimabromide has a new tetracyclic carbon skeleton, comprising a brominated benzene ring, a furano lactone residue, and a cyclohexane ring, bridged by a seven‐membered cyclic moiety. The absolute configuration was deduced from experimental and calculated CD data. Salimabromide revealed antibiotic activity towards Arthrobacter cristallopoietes. |
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| Keywords: | enhygromyxa myxobacteria natural products NMR spectroscopy polyketides |
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