Parahydrogen‐Induced Polarization Transfer to 19F in Perfluorocarbons for 19F NMR Spectroscopy and MRI |
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| Authors: | Dr. Markus Plaumann Dr. Ute Bommerich Dipl.‐Phys. Thomas Trantzschel Dipl.‐Ing. Denise Lego Dipl.‐Chem. Sonja Dillenberger Dipl.‐Chem. Grit Sauer Prof. Dr. Joachim Bargon Prof. Dr. Gerd Buntkowsky Prof. Dr. Johannes Bernarding |
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| Affiliation: | 1. Department of Biometry and Medical Informatics, Otto‐von‐Guericke University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg (Germany), Fax: (+49)?391‐67‐13536;2. Leibniz‐Institute for Neurobiology, 39118 Magdeburg (Germany);3. Eduard‐Zintl‐Institute for Inorganic Chemistry, Technical University Darmstadt, 64287 Darmstadt (Germany);4. Institute of Physical and Theoretical Chemistry, University Bonn, 53115 Bonn (Germany) |
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| Abstract: | Fluorinated substances are important in chemistry, industry, and the life sciences. In a new approach, parahydrogen‐induced polarization (PHIP) is applied to enhance 19F MR signals of (perfluoro‐n‐hexyl)ethene and (perfluoro‐n‐hexyl)ethane. Unexpectedly, the end‐standing CF3 group exhibits the highest amount of polarization despite the negligible coupling to the added protons. To clarify this non‐intuitive distribution of polarization, signal enhancements in deuterated chloroform and acetone were compared and 19F–19F NOESY spectra, as well as 19F T1 values were measured by NMR spectroscopy. By using the well separated and enhanced signal of the CF3 group, first 19F MR images of hyperpolarized linear semifluorinated alkenes were recorded. |
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| Keywords: | fluorine hydrogenation imaging agents NMR spectroscopy polarization transfer |
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