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Development of a Metal‐Ion‐Mediated Base Pair for Electron Transfer in DNA |
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| Authors: | Dr Thomas Ehrenschwender Dr Wolfgang Schmucker Christian Wellner Dipl‐Chem Timo Augenstein Dr Patrick Carl Dr Jeffrey Harmer Prof?Dr Frank Breher Prof?Dr Hans‐Achim Wagenknecht |
| Institution: | 1. Karlsruhe Institute of Technology (KIT), Institute of Organic Chemistry, Fritz‐Haber‐Weg 6, 76131 Karlsruhe (Germany), Fax: (+49)?721‐608‐44825;2. Karlsruhe Institute of Technology (KIT), Institute of Inorganic Chemistry, Engesserstrasse 15, 76131 Karlsruhe (Germany), Fax: (+49)?721‐608‐47021;3. Bruker BioSpin GmbH, Silberstreifen 4, 76287 Rheinstetten (Germany);4. Centre for Advanced Imaging, University of Queensland, St Lucia, QLD, 4072 (Australia) |
| Abstract: | A new C‐nucleoside structurally based on the hydroxyquinoline ligand was synthesized that is able to form stable pairs in DNA in both the absence and the presence of metal ions. The interactions between the metal centers in adjacent CuII‐mediated base pairs in DNA were probed by electron paramagnetic resonance (EPR) spectroscopy. The metal–metal distance falls into the range of previously reported values. Fluorescence studies with a donor–DNA–acceptor system indicate that photoinduced charge‐transfer processes across these metal‐ion‐mediated base pairs in DNA occur more efficiently than over natural base pairs. |
| Keywords: | copper DNA donor– acceptor systems electron transfer nucleosides |