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Multifunctional Core‐Shell‐Corona‐Type Polymeric Micelles for Anticancer Drug‐Delivery and Imaging |
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| Authors: | Dr. Bishnu Prasad Bastakoti Prof. Kevin C.‐W. Wu Dr. Masamichi Inoue Prof. Shin‐ichi Yusa Prof. Kenichi Nakashima Prof. Yusuke Yamauchi |
| Affiliation: | 1. World Premier International (WPI), Research Center for Materials, Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1–1 Namiki, Tsukuba, Ibaraki 305‐0044 (Japan);2. Department of Chemical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617 (Taiwan);3. Department of Materials Science and Chemistry, University of Hyogo, 2167 Shosha, Himeji 671‐2280 (Japan);4. Department of Chemistry, Faculty of Science and Engineering, Saga University, 1 Honjo‐machi, Saga 840‐8502 (Japan);5. PRESTO, Japan Science and Technology Agency (JST), Saitama (Japan);6. Faculty of Science and Engineering, Waseda University, 3‐4‐1 Okubo, Shinjuku, Tokyo 169‐8555 (Japan) |
| Abstract: | We have developed core‐shell‐corona‐type polymeric micelles that can integrate multiple functions in one system, including the capability of accommodating hydrophobic dyes into core and hydrophilic drug into the shell, as well as pH‐triggered drug‐release. The neutral and hydrophilic corona sterically stabilizes the multifunctional polymeric micelles in aqueous solution. The mineralization of calcium phosphate (CaP) on the PAA domain not only enhances the diagnostic efficacy of organic dyes, but also works as a diffusion barrier for the controlled release. |
| Keywords: | cancer cisplatin drug delivery fluorescent probes micelles |