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Cu‐Catalyzed Asymmetric Allylic Alkylation of Phosphonates and Phosphine Oxides with Grignard Reagents |
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| Authors: | Dr. Valentín Hornillos Dr. Manuel Pérez Dr. Martín Fañanás‐Mastral Prof. Dr. Ben L. Feringa |
| Affiliation: | Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen (The Netherlands), Fax: (+31)?50‐363‐4296 |
| Abstract: | An efficient and highly enantioselective copper‐catalyzed allylic alkylation of phosphonates and phosphine oxides with Grignard reagents and Taniaphos or phosphoramidites as chiral ligands is reported. Transformation of these products leads to a variety of new phosphorus‐containing chiral intermediates. |
| Keywords: | alkylation allylic compounds chirality copper Grignard reagents phosphanes |