1. Department of Chemistry, National Tsing Hua University, No. 101, Section 2, Kuang Fu Road, Hsinchu 300 (Taiwan), Fax: (+886)?3‐5711082;2. Institute of Biological Chemistry, Academia Sinica, Taipei 115 (Taiwan)
Abstract:
A method for the stereocontrolled synthesis of a bacterial phosphoglycolipid (PGL 1 ) isolated from thermophilic bacteria is described. The key features of the synthesis include a highly α‐selective glycosylation reaction between a trichloroacetimidate donor and a D ‐lyxose‐derived primary alcohol acceptor and the late‐stage incorporation of the phospholipid.