Modular Columnar Supramolecular Polymers as Scaffolds for Biomedical Applications |
| |
| Authors: | Dr. Katja Petkau‐Milroy Dr. Michael H. Sonntag Prof. Dr. Luc Brunsveld |
| |
| Affiliation: | Laboratory of Chemical Biology and Institute of Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, Den Dolech 2, 5612 AZ Eindhoven (the Netherlands), Fax: (+31)?40‐2478367 |
| |
| Abstract: | Self‐assembly of discotic molecules into supramolecular polymers offers a flexible approach for the generation of multicomponent one‐dimensional columnar architectures with tuneable biomedical properties. Decoration with ligands induces specific binding of the self‐assembled scaffold to biological targets. The modular design allows the easy co‐assembly of different discotics for the generation of probes for targeted imaging and cellular targeting with adjustable ligand density and composition. |
| |
| Keywords: | discotics molecular imaging self‐assembly supramolecular chemical biology supramolecular chemistry |
|
