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“Clickable” Hydrosoluble PEGylated Cryptophane as a Universal Platform for 129Xe Magnetic Resonance Imaging Biosensors |
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| Authors: | Dr Léa Delacour Dr Naoko Kotera Dr Ténin Traoré Sébastien Garcia‐Argote Céline Puente Dr François Leteurtre Dr Edmond Gravel Dr Nawal Tassali Dr Céline Boutin Estelle Léonce Dr Yves Boulard Dr Patrick Berthault Dr Bernard Rousseau |
| Institution: | 1. iBiTecS, Service de Chimie Bioorganique et de Marquage (SCBM), CEA, 91191 Gif‐sur‐Yvette (France), Fax: (+33)?1‐69‐08‐79‐91;2. iBiTecS, Service de Biologie Intégrative et de Génétique Moléculaire (SBIGeM), CEA, 91191 Gif‐sur‐Yvette (France);3. IRAMIS, Service Interdisciplinaire sur les Systèmes, Moléculaires et les Matériaux (SIS2M), Laboratoire Structure et Dynamique par Résonance Magnétique, CEA, 91191 Gif‐sur‐Yvette (France) |
| Abstract: | We describe the synthesis of a highly water‐soluble cryptophane 1 that can be seen as a universal platform for the construction of 129Xe magnetic resonance imaging (MRI)‐based biosensors. Compound 1 is easily functionalized by Huisgen cycloaddition and exhibits excellent xenon‐encapsulation properties. In addition, 1 is nontoxic at the concentrations typically used for hyperpolarized 129Xe MRI. |
| Keywords: | biosensors cage compounds click chemistry cryptophane NMR spectroscopy xenon |