Use of simplex optimization to improve the performance of an inductively coupled plasma in atomic emission spectrometry |
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| Institution: | 1. School of Industrial Engineering, College of Engineering, University of Tehran, Tehran, Iran;2. Universal Scientific Education and Research Network (USERN), Tehran, Iran;3. Arts et Métiers ParisTech, LCFC, Metz, France;1. Discovery Toxicology, Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ, USA;2. Discovery Biology, Bristol Myers Squibb, Princeton, NJ, USA;3. Discovery Chemistry, Bristol Myers Squibb, Princeton, NJ, USA;4. Nonclinical Safety, Bristol Myers Squibb, New Brunswick, NJ, USA;5. Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ, USA |
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| Abstract: | Simplex methods are used in the optimization of many analytical techniques. In inductively coupled plasma—atomic emission spectrometry, various performance criteria can be used, including signal-to-background ratios, signal-to-noise ratios, detection limits, and the minimization of matrix effects. The simplex method can indicate deficiencies in equipment design that restrain performance. The threshold of auto-optimization of analytical instruments has been reached. |
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